I’m having alot of difficulty with this. After many hours I was finally able to install ADE using winetricks (was impossible with just Wine) . Then in the final step in calibre, trying to customize the plugin, and it asks for the Wineprefix, nothing is working. I found some discussion online and it suggests “~/.local/share/wineprefixes/adobe_diged”, so I tried that but it doesn’t work, nor another suggestion on that page: “In WINEPREFIX put in /home/YOURUSERNAME/.adewine” . Whatever I enter for the wineprefix it just says “The Default encryption key for Adobe Digital editions could not be found”. So I’m giving up for now after struggling with this all night…